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CRKRS Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. p-7211450 Shop All Proteintech Group Inc Products
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50-173-5465 150 μL
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Catalog No. 50-173-5465 Supplier Proteintech Group Inc Supplier No. 268161AP150UL
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Description

Rabbit Polyclonal Antibody

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AG][AG]-3′), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a domit repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Specifications

Antigen CRKRS
Applications Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene CDK12
Gene Accession No. Q9NYV4
Gene Alias CDC2 related protein kinase 7, CDK12, CRK7, CRKR, CRKRS, KIAA0904
Gene Symbols CDK12
Host Species Rabbit
Immunogen CRKRS Fusion Protein Ag25323
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51755
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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