CRKRS Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-5465	Proteintech Group Inc 268161AP150UL	150 μL

Description

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5′-GTGACGT[AG][AG]-3′), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a domit repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Specifications

• Antigen: CRKRS
• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q9NYV4
• Gene ID (Entrez): 51755
• Immunogen: CRKRS Fusion Protein Ag25323
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CDK12

• Concentration: 0.4 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: CDC2 related protein kinase 7, CDK12, CRK7, CRKR, CRKRS, KIAA0904
• Gene Symbols: CDK12
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody