Invitrogen™ CRMP5 Monoclonal Antibody (CR-3)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA3700

Catalog No. MA3-700

Description

MA3-700 detects human, bovine, rat and mouse N-terminal region of CRMP5. MA3-700 has been successfully used in Western blot and immunohistochemical procedures. By Western blot, this antibody detects an ~ 62 kDa protein corresponding to human CRMP5 from brain extract. The MA3-700 antigen is a purified protein from human brain. This antibody is specific for the N-terminal region, amino acids 1-64. Not reactive with other CRMP isoforms.

The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked to paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.

Specifications

• Antigen: CRMP5
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.05% sodium azide
• Gene Accession No.: Q9BPU6, Q9EQF6, Q9JHU0
• Gene Symbols: DPYSL5
• Immunogen: CRMP5 protein purified from human brain.
• Regulatory Status: RUO
• Gene ID (Entrez): 100126171, 56896, 65208, 65254
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: CR-3
• Conjugate: Unconjugated
• Gene: DPYSL5
• Gene Alias: collapsin response mediator protein 5; collapsin response mediator protein-5; CRAM; CRMP3-associated molecule; Crmp5; CRMP-5; dihydropyrimidinase like 5; dihydropyrimidinase-like 5; dihydropyrimidinase-related protein 5; Dpysl5; DRP-5; Ulip6; ULIP-6; ULIP6 protein; UNC33-like phosphoprotein 6
• Host Species: Rat
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Bovine
• Product Type: Antibody
• Isotype: IgG2a