Invitrogen™ CRP Monoclonal Antibody (P4D7)

Catalog No.	Quantity
PIMIC0501	1 mg

Catalog No. PIMIC0501 Supplier Invitrogen™ Supplier No. MIC0501

Description

Mouse Monoclonal Antibody

MIC0501 targets C Reactive Protein in ELISA, IP, and RIA applications and shows reactivity with Human samples. The MIC0501 immunogen is purified human plasma CRP. MIC0501 detects C Reactive Protein which has a predicted molecular weight of approximately 23 kDa. MIC0501 was formerly sold as a Seradyn product.

CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits. Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa. CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance. Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation. CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. CRP is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host, and initiates pathogen elimination by interacting with humoral and cellular effector systems in the blood. Patients with elevated basal levels of CRP have been shown to be an increased risk for hypertension and cardiovascular disease.

Specifications

• Antigen: CRP
• Applications: ELISA, Immunoprecipitation, Radioimmune Assays (RIA), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: P4D7
• Concentration: 5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: Crp
• Gene Accession No.: P02741, P14847
• Gene Alias: Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262; Ac2-069; acute phase protein; CRP; AI255847; Ba2-693; c reactive; C-reactive preprotein; C-reactive protein; C-reactive protein member of the pentraxin family; C-reactive protein(1-205); C-reactive protein, member of the pentraxin family; C-reactive protein, pentraxin-related; C-reactive protein, petaxin related; CRP; CRP1; CSRP; CYRP; D1S181E; DKFZp686M148; DKFZp686M149; MGC149895; MGC88244; pentraxin 1; PTX1; RP11-419N10.4
• Gene Symbols: Crp
• Host Species: Mouse
• Immunogen: Purified human plasma CRP.
• Purification Method: Ion-exchange chromatography
• Quantity: 1 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12944, 1401
• Target Species: Human, Mouse
• Content And Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov