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CRYAB Mouse anti-Human, Clone: OTI6G5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF500599

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintece. Alpha-B crystallin has been linked to Alexander′s disease where it accumulates in brain cells of those afflicted.Specifications
CRYAB | |
Monoclonal | |
Unconjugated | |
CRYAB | |
CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2 | |
Mouse | |
Affinity Chromatography | |
RUO | |
1410 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
OTI6G5 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P02511 | |
CRYAB | |
Full length human recombit protein of human CRYAB produced in HEK293T cell. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
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