CRYAB Mouse anti-Human, Clone: OTI6G5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500599

Catalog No. 50-165-9669

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintece. Alpha-B crystallin has been linked to Alexander′s disease where it accumulates in brain cells of those afflicted.

Specifications

• Antigen: CRYAB
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CRYAB
• Gene Alias: CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1410
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: OTI6G5
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P02511
• Gene Symbols: CRYAB
• Immunogen: Full length human recombit protein of human CRYAB produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b