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Invitrogen™ CRYBB2 Polyclonal Antibody
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Catalog No. PIPA5102805
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PIPA5102805 100 μL
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Catalog No. PIPA5102805 Supplier Invitrogen™ Supplier No. PA5102805
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CRYBB2.

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CRYBB2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Crybb2
Gene Accession No. P43320, P62696, P62697
Gene Alias Beta crystallin B2; Beta crystallin Bp; beta-B2 crystallin; Beta-crystallin B2; beta-crystallin Bp; CCA 2; CCA2; CRYB B2; CRYB2; Cryb-2; CRYB2A; CRYBB 2; CRYBB2; crystallin beta B2; crystallin, beta B2; CTA-221G9.7; CTRCT3; D22S665; eye lens structural protein; OTTHUMP00000198622; R.norvegicus CRYBB2 gene (crystallin, beta B2)
Gene Symbols Crybb2
Host Species Rabbit
Immunogen A synthesized peptide derived from human CRYBB2(Accession P43320), corresponding to amino acid residues G61-L111.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12961, 1415, 25422
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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