CSN7b Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-155-6785	100 μL

Catalog No. 50-155-6785

Supplier: Bethyl Laboratories, Inc A300044A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse and Bovine

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Specifications

• Antigen: CSN7b
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: COPS7B
• Gene Accession No.: Q9H9Q2
• Gene Alias: COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 7B, COP9 constitutive photomorphogenic homolog subunit 7B, COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis), CSN7B, JAB1-containing signalosome subunit 7b, SGN7b, signalosome subunit 7b
• Gene Symbols: COPS7B
• Host Species: Rabbit
• Immunogen: Between 225 and C-term
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 64708
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG