CTLA4 Mouse anti-Human, Clone: UMAB249, lyophilized, UltraMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene UM800141CF

Catalog No. 50-168-5408

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhibits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.

Specifications

• Antigen: CTLA4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CTLA4
• Gene Alias: ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1493
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin)
• Clone: UMAB249
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P16410
• Gene Symbols: CTLA4
• Immunogen: Full length human recombit protein of human CTLA4 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1