Invitrogen™ CTPS Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536378

Catalog No. PIPA536378

Description

This antibody detects endogenous protein at a molecular weight of 67 kDa. Purity is >95% by SDS-PAGE.

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.

Specifications

• Antigen: CTPS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CTPS1
• Gene Alias: cb1040; CTP synthase; CTP synthase 1; CTP synthase 1a; CTP synthase a; CTP synthetase 1; CTPS; ctps1; ctps1a; ctpsa; cytidine 5-prime triphosphate synthetase; cytidine 5'-triphosphate synthase; cytidine 5'-triphosphate synthetase; IMD24; UTP--ammonia ligase 1; wu:fb49e03; wu:fe17b03
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1503, 313560, 51797
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P17812, P70698
• Gene Symbols: Ctps, CTPS1
• Immunogen: Synthetic peptide corresponding to amino acids 80-130 of human CTPS.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG