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Invitrogen™ CTRB2 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA5121484
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PIPA5121484 20 μL
PIPA5121483 100 μL
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Catalog No. PIPA5121484 Supplier Invitrogen™ Supplier No. PA5121484
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Description

Rabbit Polyclonal Antibody

CTRB2 (Chymotrypsinogen B2) is a Protein Coding gene. Diseases associated with CTRB2 include Pancreatitis. Among its related pathways are Cobalamin (Cbl, vitamin B12) transport and metabolism and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRB1. This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This CTRB2 gene is located head-to-head with the related CTRB1 gene. Some human populations have an alternate haplotype which inverts a 16.6 Kb region containing portions of intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2 genes. In this inversion haplotype exon 1 and flanking sequence is swapped in CTRB1 and CTRB2. This inversion is associated with differential gene expression and increased risk for chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 of the CTRB1 gene. SNP rs8048956 is diagnostic for this inversion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CTRB2
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene CTRB2
Gene Accession No. Q6GPI1
Gene Alias Chymotrypsin B2
Gene Symbols CTRB2
Host Species Rabbit
Immunogen Ile34-Asn263 (Accession Q6GPI1), with N-terminal His and GST Tag.
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 440387
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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