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Cayman Chemical TetrahydroepIberberIn 25mg
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Supplier:  Cayman Chemical 3617725 MG

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An IGF-1R inhibitor (IC50 0 15 UM in a cell-free assay) selective for IGF-1R over a panel of 20 kinases but also inhibits InsR FLT1 FLT3 and Tie2 (IC50s 0 14 0 6 0 42 and 0 53 UM respectively in cell-free assays) selectively inhibits the autophosphorylation of IGF-1R over InsR EGFR PDGFR c-Kit and Bcr-Abl in cells (IC50s 0 086 2 3 10 10 5 and 10 UM respectively) reduces tumor volume in an NWT-21 murine fibrosarcoma model at 20 30 or 50 mg/kg twice per day

Catalog No. 50-291-1683


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