Invitrogen™ CYB561D2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575426

Catalog No. PIPA575426

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

CYB561D2 (Cytochrome b561 domain-containing protein 2), also known as putative tumor suppressor protein 101F6, is a 222 amino acid highly hydrophobic protein that contains six membrane spanning domains. Localized to endosomes and endoplasmic reticulum of the perinuclear region, CYB561D2 contains 2 heme-binding sites, through which it reduces ferric ions. CYB561D2 is ubiquitously expressed, with highest levels in lung, liver and kidney. Though expression of CYB561D2 is abundant in normal lung bronchial epithileal cells, CYB561D2 is absent in most lung cancers. The gene encoding CYB561D2 maps to human chromosome 3p21.3, a region that is prone to genetic alterations and is associated with frequent and early allele loss in many human cancers. Exogenous expression of CYB561D2 leads to the induction of caspase-independent apoptotic and autophagic pathways, resulting in the synergistic killing of tumor cells. This suggests an important role for CYB561D2 as a therapeutic intervention in cancer treatment.

Specifications

• Antigen: CYB561D2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CYB561D2
• Gene Alias: 101F6; 101F6 protein; AW049681; CYB561D2; cytochrome b-561 domain containing 2; cytochrome b561 domain-containing protein 2; cytochrome b561 family member D2; cytochrome b561 family, member D2; gene for 101F6 protein; LUCA12.2; OTTHUMP0000021067; OTTHUMP00000210675; OTTHUMP00000210676; Putative tumor suppressor protein 101F6; Transmembrane ascorbate ferrireductase; Tsp10; tumor suppressor, region 10; XXcos-LUCA11.4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11068, 363137, 56368
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide
• Gene Accession No.: O14569, Q641Y1, Q9WUE3
• Gene Symbols: CYB561D2
• Immunogen: Synthetic peptide corresponding to amino acids 61-110 of Human CYB561D2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG