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Thermo Scientific™ Lab Vision™ Cyclin B1 Ab-2, Rabbit Polyclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments.

Specifications

Antigen Cyclin B1 Ab-2
Clone Polyclonal
Concentration 1mg/mL
Applications Immunoprecipitation
Classification Polyclonal
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Products 4
Catalog Number Mfr. No. Formulation Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Formulation Quantity Price Quantity & Availability  
RB008P0
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Thermo Scientific™
RB008P0
Purified Ab with BSA and Azide 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
RB008P
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Thermo Scientific™
RB008P
Purified Ab with BSA and Azide 1mL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
RB008P1ABX
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Thermo Scientific™
RB008P1ABX
Ab without BSA/Azide (Frozen) 500μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
RB008PABX
View Documents
Thermo Scientific™
RB008PABX
Ab without BSA/Azide (Frozen) 1mL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Ensure accurate, reproducible results in Immunohistochemistry, Western Blotting and Immunoprecipitation experiments with Thermo Scientific™ Cyclin B1 Ab-2, Rabbit Polyclonal Antibody.

In mammals, cyclin B associates with inactive p34cdc2 which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Mouse and Rat. Others not known.

Epitope: C-terminal

Immunogen: A synthetic peptide derived from the C-terminus of human cyclin B1

Molecular Weight: 62 kDa

Positive Control: Jurkat, Ls174T, HeLa cells; Breast CA

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

Cyclin B1 Ab-2
1mg/mL
Polyclonal
Concentrated
RUO
Primary
IgG
Polyclonal
Immunoprecipitation
Unconjugated
Rabbit
Cell Cycle
A synthetic peptide derived from the C-terminus of human cyclin B1
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