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Invitrogen™ Cyclin D3 Monoclonal Antibody (DCS-22)
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Catalog No. PIMA512717
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500 μL
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PIMA512717 500 μL
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Catalog No. PIMA512717 Supplier Invitrogen™ Supplier No. MA512717
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Description

Mouse Monoclonal Antibody

MA5-12717 targets Cyclin D3 in FACS, IF, IHC (P), IP, and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples. The MA5-12717 immunogen is purified human recombinant full length cyclin D3 protein.

The protein encoded by this gene belongs to the highly conservedcyclinfamily, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases. Differentcyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Thiscyclinforms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with thiscyclinwas reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyclin D3
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone DCS-22
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene CCND3
Gene Accession No. P30281, P30282, P48961
Gene Alias 9230106B05Rik; AA682053; AL024085; AW146355; C78795; CCND 3; Ccnd3; CGD3; cyclin D3; CyclinD3; Cyl-3; D3 type cyclin; D3-type cyclin; G1/S-specific cyclin-D3; OTTHUMP00000223415; RP5-973N23.3
Gene Symbols CCND3
Host Species Mouse
Immunogen Purified human recombinant full length cyclin D3 protein.
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12445, 25193, 896
Target Species Human, Mouse, Monkey, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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