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Invitrogen™ Cyclophilin A Monoclonal Antibody (C1)

Mouse Monoclonal Antibody

$213.50 - $522.50

Specifications

Antigen Cyclophilin A
Clone C1
Concentration 1 mg/mL
Content And Storage -20°C
Applications Immunohistochemistry (Paraffin), Western Blot
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIMA541575
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Invitrogen™
MA541575
200 μL
Each for $522.50
Only null left
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PIMA543861
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Invitrogen™
MA543861
20 μL
Each for $213.50
Only null left
Add to Cart
 
Description

Description

Cyclophilin A Monoclonal Antibody for Western Blot, IHC (P)

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.
Specifications

Specifications

Cyclophilin A
1 mg/mL
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Mouse
RUO
PBS with 50% glycerol and 0.05% ProClin 300
P62937
5478
Recombinant protein Cyclophilin A. The antigen corresponds to amino acid range 2-165 of the target protein.
Antibody
C1
-20°C
Monoclonal
Liquid
IgG2a κ
Human
Ppia
2700098C05; Cphn; CYCA; cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; CyP-18; CYPA; CyP-A; CYPH; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p; HEL-S-69p; HGNC:9253; I79_011869; MGC117158; MGC12404; MGC23397; p1B15; p31; Peptidyl-prolyl cis-trans isomerase A; Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; peptidylprolyl isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIA; PPIase; PPIase A; rotamase; rotamase A; SP18; T cell cyclophilin
Ppia
Primary
Protein A/G
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