Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ Cyclophilin A Monoclonal Antibody (C1)
Mouse Monoclonal Antibody
$213.50 - $522.50
Specifications
Antigen | Cyclophilin A |
---|---|
Clone | C1 |
Concentration | 1 mg/mL |
Content And Storage | -20°C |
Applications | Immunohistochemistry (Paraffin), Western Blot |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
PIMA541575
|
Invitrogen™
MA541575 |
200 μL |
Each for $522.50
|
|
|||||
PIMA543861
|
Invitrogen™
MA543861 |
20 μL |
Each for $213.50
|
|
|||||
Description
Cyclophilin A Monoclonal Antibody for Western Blot, IHC (P)
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.Specifications
Cyclophilin A | |
1 mg/mL | |
Immunohistochemistry (Paraffin), Western Blot | |
Unconjugated | |
Mouse | |
RUO | |
PBS with 50% glycerol and 0.05% ProClin 300 | |
P62937 | |
5478 | |
Recombinant protein Cyclophilin A. The antigen corresponds to amino acid range 2-165 of the target protein. | |
Antibody |
C1 | |
-20°C | |
Monoclonal | |
Liquid | |
IgG2a κ | |
Human | |
Ppia | |
2700098C05; Cphn; CYCA; cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; CyP-18; CYPA; CyP-A; CYPH; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p; HEL-S-69p; HGNC:9253; I79_011869; MGC117158; MGC12404; MGC23397; p1B15; p31; Peptidyl-prolyl cis-trans isomerase A; Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; peptidylprolyl isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIA; PPIase; PPIase A; rotamase; rotamase A; SP18; T cell cyclophilin | |
Ppia | |
Primary | |
Protein A/G |
Spot an opportunity for improvement?Share a Content Correction
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title