Invitrogen™ Cyclophilin B Recombinant Rabbit Monoclonal Antibody (3H9L48)

Catalog No.	Quantity
70-500-0	100 μL

Catalog No. 70-500-0 Supplier Invitrogen™ Supplier No. 705000

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant Rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

Specifications

• Antigen: Cyclophilin B
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: 3H9L48
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: PPIB
• Gene Accession No.: P23284
• Gene Alias: AA408962; AA553318; AI844835; Cphn2; Cphn-2; cyclophilin B; cyclophilin-like protein; Cyp B; CyP-20b; CYPB; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; HEL-S-39; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Ppib; Rotamase; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP
• Gene Symbols: PPIB
• Host Species: Rabbit
• Immunogen: Protein corresponding to human Cyclophilin B [aa34-aa216].
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5479
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG