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Apexbio Technology LLC Nalidixic acid 389-08-2 10mM (in 1mL DMSO)

Supplier: Apexbio Technology LLC B19855.1

Nalidixic acid is a quinolone-class antibacterial agent targeting bacterial DNA gyrase and topoisomerase IV enzymes essential for bacterial DNA replication and topology maintenance Its mechanism involves disruption of DNA supercoiling and replication processes exhibiting bacteriostatic activity at lower concentrations and bactericidal effects when concentration increases Nalidixic acid is typically employed in microbiological studies for antibacterial mechanistic research antibiotic resistance characterization and screening bacterial strains with altered gyrase or topoisomerase IV susceptibilities Reported IC50 values against DNA gyrase typically range from 10 to 50 M depending on bacterial species and experimental conditions
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