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Cyclosporin A, 99+%

Catalog No. AAJ6319103
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Quantity:
1 g
5 g

Cyclosporin A, CAS # 59865-13-3, is a compound that shows immunosuppressive, antifungal, antirheumatic, and dermatologic activities. It is also a calcineurin and enzyme inhibitor. | CAS: 59865-13-3 | C62H111N11O12 | 1202.64 g/mol

Ciclosporin A induces apoptosis and inhibits angiogenesis induced by VEGF. It also suppresses the replication of hepatitis C virus genome in cultured hepatocytes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum

Applications

  • It inhibits phosphoprotein phosphatase
  • Cyclosporin A binds to the cellular protein cytophilin and inhibits the enzyme calcineurin
  • Furthermore, it can induce apoptosis and inhibit angiogenesis induced by VEGF
  • It exerts potent immunosuppressive activity on T immune cells, and causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle
  • It also suppresses the hepatitis C virus replication in cultured hepatocytes
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 59865-13-3
Molecular Formula C62H111N11O12
Molecular Weight (g/mol) 1202.64
MDL Number MFCD00274558
InChI Key PMATZTZNYRCHOR-IMVLJIQENA-N
Synonym Cyclosporine A; Antibiotic S 7481F1
PubChem CID 132274082
IUPAC Name 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
SMILES CCC1NC(=O)C(C(O)C(C)C\C=C\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

Specifications

Type Cyclosporin A
Physical Form Crystalline Solid
Melting Point 146°C to 151°C
Color White
Quantity 1 g
Beilstein 3647785
Merck Index 14,2752
Solubility Information Soluble in dimethyl sulfoxide and ethanol; Insoluble in water.
Formula Weight 1202.61
Percent Purity ≥99%
Chemical Name or Material Cyclosporin A
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Hazard Category H302-H350-H360FD
Hazard Statement GHS H Statement
H361-H302
Suspected of damaging fertility or the unborn child.
Harmful if swallowed.
Precautionary Statement P201-P202-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
EINECSNumber 611-907-1
RTECSNumber GZ4120000
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only

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