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CYFIP1/2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. p-7206465 Shop All Proteintech Group Inc Products
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50-173-0640 150 μL
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Catalog No. 50-173-0640 Supplier Proteintech Group Inc Supplier No. 160111AP150UL
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Description

Rabbit Polyclonal Antibody

This antibody can recognize both CYFIP1 and CYFIP2.

CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1, 278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

Specifications

Antigen CYFIP1/2
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.19 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CYFIP1
Gene Accession No. Q5SQX6, Q7L576, Q7TMB8, Q96F07
Gene Alias CYFIP2, KIAA1168, p53 inducible protein 121, PIR121
Gene Symbols Cyfip1, Cyfip2
Host Species Rabbit
Immunogen CYFIP1/2 Fusion Protein Ag8749
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20430, 23191, 26999, 76884
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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