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Invitrogen™ CYFIP2 Polyclonal Antibody
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Catalog No. PA550388
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100 μL
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PA550388 100 μL
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Catalog No. PA550388 Supplier Invitrogen™ Supplier No. PA550388
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total CYFIP2 / PIR121 protein.

CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYFIP2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene CYFIP2
Gene Accession No. Q5SQX6, Q96F07
Gene Alias 1500004I01Rik; 6430511D02Rik; AA930218; AU022376; cyfip2; cytoplasmic FMR1 interacting protein 2; cytoplasmic FMR1-interacting protein 2; Kiaa1168; mKIAA1168; p53-inducible protein 121; PIR121
Gene Symbols CYFIP2
Host Species Rabbit
Immunogen Fusion protein corresponding to residues near the C terminal of human cytoplasmic FMR1 interacting protein 2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26999, 76884
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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