Invitrogen™ CYP1A1/CYP1A2 Monoclonal Antibody (MC1)

Catalog No.	Quantity
01-670-132	100 μL

Catalog No. 01-670-132 Supplier Invitrogen™ Supplier No. MA3036

Description

Mouse Monoclonal Antibody

MA3-036 detects Cytochrome P450 1A1/1A2 from human, primate, rat and mouse samples. MA3-036 has been successfully used in Western blot, immunocytochemistry, immunofluorescence and immunohistochemisty (paraffin) applications. By Western blot, this antibody detects a ~58 kDa band representing Cytochrome P450 1A1/1A2. The MA3-036 immunogen is 3-methylcholanthrene induced rat cytochrome P450 protein.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

Specifications

• Antigen: CYP1A1/CYP1A2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: MC1
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: Ascites with 0.05% sodium azide
• Gene: CYP1A2
• Gene Accession No.: P00184, P00185, P00186, P04798, P04799, P05177
• Gene Alias: AHH; AHRR; aromatic compound inducible; aryl hydrocarbon hydroxylase; cholesterol 25-hydroxylase; CP11; CP12; CYP1; Cyp1a1; Cyp1a-1; CYP1A2; Cyp1a-2; Cyp45c; Cypc45c; CYPD45; CYPIA1; CYPIA2; Cytochrome P(3)450; cytochrome P1-450; cytochrome P1-450, dioxin-inducible; Cytochrome P3 450; cytochrome P-448; cytochrome P450 1A1; Cytochrome P450 1A2; cytochrome P450 4; cytochrome P450 family 1 subfamily A member 1; cytochrome P450 family 1 subfamily A member 2; cytochrome P450 family 1 subfamily a polypeptide 1; cytochrome P450 family 1 subfamily a polypeptide 2; cytochrome P450 form 6; cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c); Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); cytochrome P450 subfamily I, polypeptide 1; cytochrome P450, 1a1; cytochrome P450, 1a1, aromatic compound inducible; cytochrome P450, 1a2; cytochrome P450, 1a2, aromatic compound inducible; cytochrome P450, family 1, subfamily a, polypeptide 1; cytochrome P450, family 1, subfamily a, polypeptide 2; cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c); cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; cytochrome P450-C; Cytochrome P-450d; Cytochrome P450-D; Cytochrome P450MT2; Cytochrome P450MT2A; Cytochrome P450MT2B; cytochrome P450-P1; Cytochrome P450-P2; cytochrome P450-P3; dioxin-inducible; dioxin-inducible P3-450; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P1-450; P3-450; P-448; P450 form 4; P450(PA); P450-1; P450-3; P450-C; P-450d; P450-D; P450DX; P450form6; P-450MC; P450MT2; RATCYPD45; xenobiotic monooxygenase
• Gene Symbols: CYP1A1, CYP1A2
• Host Species: Mouse
• Immunogen: 3-methylcholanthrene induced rat cytochrome P450 protein.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 13076, 13077, 1543, 1544, 24296, 24297
• Target Species: Human, Mouse, Monkey, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1