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Invitrogen™ CYP1B1 Polyclonal Antibody
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Catalog No. PIPA595277
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PIPA595277 100 μg
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Catalog No. PIPA595277 Supplier Invitrogen™ Supplier No. PA595277
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Description

Rabbit Polyclonal Antibody

Human CYP1B1 shares 85.4% and 84.5% amino acid (aa) sequence identity with mouse and rat CYP1B1, respectively. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human MCF-7 whole cell, human PC-3 whole cell, rat heart tissue, mouse heart tissue. IHC: Mouse Kidney tissue, Rat Kidney tissue, Human Liver Cancer tissue. Flow: SiHa cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP1B1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg sodium azide
Gene Cyp1b1
Gene Accession No. Q16678, Q64429, Q64678
Gene Alias aryl hydrocarbon hydroxylase; benz[a]anthracene inducible; CP1B; CYP1B; CYP1B1; Cyp1-b1; CYPIB1; cytochrome P450 1B; cytochrome P450 1B1; cytochrome P450 family 1 subfamily B member 1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); cytochrome P4501B; cytochrome P450CMEF; Cytochrome P450EF; cytochrome P450RAP; flavoprotein-linked monooxygenase; GLC3A; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P4501B1; P450RAP; xenobiotic monooxygenase; zgc:136223
Gene Symbols Cyp1b1
Host Species Rabbit
Immunogen E.coli-derived human CYP1B1 recombinant protein (Position: R255-L480).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13078, 1545, 25426
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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