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Invitrogen™ CYP27A1 Polyclonal Antibody
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Catalog No. PIPA563674
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PIPA563674 100 μL
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Catalog No. PIPA563674 Supplier Invitrogen™ Supplier No. PA563674
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RQRSLEEIPR LGQLRFFFQL FVQGYALQLH QLQVLYKAKY GPMWMSYLGP QMHVNLASAP LLEQVMRQEG KYPVRNDMEL WKEHRDQHDL TYGPFTTEGH HWYQLRQALN QRLLKPAEAA LYTDAFNEVI DDFMTRLD Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 69%.

CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways. [1] It is the initiating enzyme in the acidic pathway to bile acids, yielding oxysterols by introducing a hydroxyl group to the carbon at the 27 position in cholesterol. In the acidic pathway, it produces 27-hydroxycholesterol from cholesterol whereas in the classic or neutral pathway, it produces 3beta-hydroxy-5-cholestenoic acid. It is also involved in the metabolism of vitamin D3. While CYP27A1 is present in many different tissues, its function in these tissues is largely uncharacterized. In macrophages, 27-hydroxycholesterol generated by this enzyme may be helpful against the production of inflammatory factors associated with cardiovascular disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP27A1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CYP27A1
Gene Accession No. Q02318
Gene Alias 1300013A03Rik; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; cholestanetriol 26-monooxygenase; cholesterol 27 hydroxylase; CP27; CTX; CYP27; CYP27A1; cyt; cytochrome P450 27; cytochrome P450 family 27 subfamily A member 1; cytochrome P450, 27; cytochrome P450, 27a1; cytochrome P450, family 27, subfamily a, polypeptide 1; cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1; Cytochrome P-450C27/25; P450C27; Sterol 26-hydroxylase, mitochondrial; sterol 27-hydroxylase; Vitamin D(3) 25-hydroxylase
Gene Symbols CYP27A1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CYP27A1. Recombinant protein control fragment (Product #RP-90768).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1593
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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