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CYP27A1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 147391AP150UL

Encompass_Preferred

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Catalog No. 50-172-9685


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Description

Description

CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways.[1] It is the initiating enzyme in the acidic pathway to bile acids, yielding oxysterols by introducing a hydroxyl group to the carbon at the 27 position in cholesterol. In the acidic pathway, it produces 27-hydroxycholesterol from cholesterol whereas in the classic or neutral pathway, it produces 3beta-hydroxy-5-cholestenoic acid.It is also involved in the metabolism of vitamin D3. While CYP27A1 is present in many different tissues, its function in these tissues is largely uncharacterized. In macrophages, 27-hydroxycholesterol generated by this enzyme may be helpful against the production of inflammatory factors associated with cardiovascular disease.
Specifications

Specifications

CYP27A1
Polyclonal
Unconjugated
CYP27A1
CP27, CTX, CYP27, CYP27A1, Cytochrome P 450C27/25, Cytochrome P450 27, Sterol 27 hydroxylase, Vitamin D(3) 25 hydroxylase
Rabbit
Antigen Affinity Chromatography
RUO
104086, 1593, 301517
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.16 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P17178, Q02318, Q9DBG1
Cyp27a1
CYP27A1 Fusion Protein Ag6408
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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