Invitrogen™ CYP2B6 Monoclonal Antibody (OTI3D5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA525882

Catalog No. PIMA525882

Description

CYP2B6 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Specifications

• Antigen: CYP2B6
• Classification: Monoclonal
• Concentration: 1.00 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P13107, P20813, P24460
• Gene Symbols: Cyp2b3, CYP2B6
• Immunogen: Full length human recombinant protein of CYP2B6 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Monkey
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: OTI3D5
• Conjugate: Unconjugated
• Gene: CYP2B6
• Gene Alias: 1,4-cineole 2-exo-monooxygenase; CPB6; CYP2B; CYP2B11; Cyp2b3; Cyp2b-3; CYP2B30; CYP2B6; CYP2B7; CYP2B7P; CYPIIB11; CYPIIB3; CYPIIB6; cytochrome P450 2B11; Cytochrome P450 2B3; cytochrome P450 2B6; cytochrome P450 CYP2B30; cytochrome P450 family 2 subfamily B member 6; cytochrome P-450 IIB; cytochrome P450 IIB1; Cytochrome P450 PBD-2; cytochrome P450, family 2, subfamily B, polypeptide 11; cytochrome P450, family 2, subfamily b, polypeptide 3; cytochrome P450, family 2, subfamily B, polypeptide 6; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6; cytochrome P450IIB3; Cytochrome-P450-2B11; EFVM; IIB1; P450
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1555, 286953, 474177
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid