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Invitrogen™ CYP2C11 Polyclonal Antibody
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Catalog No. PA3034
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100 μL
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PA3034 100 μL
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Catalog No. PA3034 Supplier Invitrogen™ Supplier No. PA3034
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Description

Rabbit Polyclonal Antibody

PA3-034 detects cytochrome P450 2C11 (P450 2C11) from human, feline and rat tissues. PA3-034 has been successfully used in Western blot, ICC/IF and immunohistochemical (frozen and paraffin) procedures. By Western blot, this antibody detects an ~50 kDa protein representing P450 2C11 from rat liver extract. Immunohistochemical staining of P450 2C11 in rat brain with PA3-034 results in perivascular staining. The PA3-034 immunogen is a synthetic peptides corresponding to residues D(49) I G Q S I K K F S K V(60) and Q(491) R A D S L S S H L(500) of rat Cytochrome P450 2C11.

The cytochrome P450 (P450) family of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as NADPH and P450 reductase. There are over 200 cDNA's which encode P450 protein. Epoxygenases are those P450 proteins which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450 proteins which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). EET's, which exhibit vasodilation activity, are formed when an epoxide group is inserted between the unsaturated carbons of AA in positions 5,6; 8,9; 11,12; 14,15. EET's are produced in cerebral cortical tissue, coronary arteries and vascular endothelium. EET's are converted from AA by the 2C11 family of P450's whose expression is induced by testosterone and is therefore not generally found in females.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP2C11
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole serum, PBS with 0.05% sodium azide
Gene Cyp2c11
Gene Accession No. P08683
Gene Alias CYP; Cyp2c; Cyp2c11; Cyp2c-11; CYP2CII; CYPIIC11; cytochrome P450 2C11; Cytochrome P-450(M-1); cytochrome P450, 2c29; cytochrome P450, subfamily 2, polypeptide 11; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase); cytochrome P450H; cytochrome P450-UT-2; Cytochrome P450-UT-A; P450; P-450(M-1); P450H; P450-UT-A; UT-2
Gene Symbols Cyp2c11
Host Species Rabbit
Immunogen Synthetic peptides corresponding to residues D(49) I G Q S I K K F S K V(60) and Q(491) R A D S L S S H L(500) of rat Cytochrome P450 2C11.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29277
Target Species Human, Rat, Feline
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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