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Invitrogen™ Cyp4a10 Polyclonal Antibody
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Catalog No. PA3033
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100 μL
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PA3033 100 μL
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Catalog No. PA3033 Supplier Invitrogen™ Supplier No. PA3033
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Description

Rabbit Polyclonal Antibody

PA3-033 detects cytochrome P450 4A (isoforms 1, 2, & 3) from human, feline, rabbit and rat tissues. PA3-033 has been successfully used in Western blot, ICC/IF and IHC procedures. By Western blot, this antibody detects an ~50 kDa protein representing P450 4A in rat liver extract. Immunohistochemical staining of P450 4A in rat brain with PA3-033 results in perivascular and surrounding cortex staining. The PA3-033 immunogen is a synthetic peptide corresponding to residues D(431) P S R F A P D S P R H S H S(445) of rat Cytochrome P450 4A.

The cytochrome P450 (P450) family of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as NADPH and P450 reductase. There are over 200 cDNA's which encode P450 protein. Epoxygenases are those P450 proteins which metabolize AA to epoxyeicosatrienoic acid (EETs) and w-hydroxylases are those P450 proteins which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). 20-HETE is converted from AA by the 4A family of P450 proteins which includes at least 8 different, though closely related isoforms. 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyp4a10
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole serum, PBS with 0.05% sodium azide
Gene Cyp4a1
Gene Accession No. P08516
Gene Alias CYP; Cyp4a1; Cyp4a-1; Cyp4a10; Cyp4a22; CYPIVA10; cytochrome P450 4A10; cytochrome P450, 4A1; cytochrome P450, 4a10; cytochrome P450, family 4, subfamily a, polypeptide 1; cytochrome P450, family 4, subfamily a, polypeptide 10; cytochrome P450, family 4, subfamily A, polypeptide 22; cytochrome P450, IVA1; cytochrome P450-LA-omega 1; Cytochrome P452; lauric acid omega-hydroxylase; Long-chain fatty acid omega-monooxygenase; P450
Gene Symbols Cyp4a1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues D(431) P S R F A P D S P R H S H S(445) of rat Cytochrome P450 4A.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50549
Target Species Human, Rat, Rabbit, Feline
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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