CYP4F3 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-2498	150 μL

Catalog No. 50-173-2498 Supplier Proteintech Group Inc Supplier No. 197011AP150UL

Description

Rabbit Polyclonal Antibody

Cytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60 kDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the u-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation. CYP4F3 exists in two functionally distinct isoforms: CYP4F3A, a neutrophil isoform, is particularly expressed in neutrophils and myeloid cells and catalyzes the microsomal u-hydroxylation of LTB4. It interacts with CD11b and myeloperoxidase on myeloid cells and regulates cellular development in bone marrow. CYP4F3B, a liver isoform, catalyzes the conversion of arachidonic acid to 20-HETE, a potent activator of PKC. Its role has been implicated in cell proliferation, vascular tone and natriuresis.

Specifications

• Antigen: CYP4F3
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.46 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: CYP4F3
• Gene Accession No.: Q08477
• Gene Alias: CPF3, CYP4F, CYP4F3, CYPIVF3, Cytochrome P450 4F3, Cytochrome P450 LTB omega, LTB4H
• Gene Symbols: CYP4F3
• Host Species: Rabbit
• Immunogen: Peptide
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4051
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG