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Invitrogen™ CYP8B1 Polyclonal Antibody
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Catalog No. PIPA537088
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PIPA537088 100 μL
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Catalog No. PIPA537088 Supplier Invitrogen™ Supplier No. PA537088
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 58 kDa. Purity is >95% by SDS-PAGE.

CYP8B1 (sterol 12-alpha-hydroxylase) is a member of the cytochrome P450 superfamily of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. CYP8B1 is highly expressed in liver and is an important enzyme for bile acid synthesis. Specifically, CYP8B1 moderates the ratio of cholic acid over chenodeoxycholic acid to control the solubility of cholesterol. The gene encoding human CYP8B1 maps to chromosome 3p22.1. The CYP8B1 gene encodes a 501-amino acid protein and does not contain any introns. The CYP8B1 gene promoter is transactivated by hepatocyte nuclear factor 4a. In mice, disruption of the CYP8B1 gene prevents the synthesis of cholate, which is a primary bile acid.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CYP8B1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene CYP8B1
Gene Accession No. O88962, Q9UNU6
Gene Alias 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; CP8B; CYP12; Cyp8b1; CYPVIIIB1; cytochrome P450 8B1; cytochrome P450 8b1 sterol 12 alpha-hydrolase; cytochrome P450 family 8 subfamily B member 1; cytochrome P450, 8b1, sterol 12 alpha-hydrolase; cytochrome P450, family 8, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1; sterol 12-alpha-hydrolase; sterol 12-alpha-hydroxylase
Gene Symbols CYP8B1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 416-461 of human CYP8B1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13124, 1582, 81924
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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