Invitrogen™ CYR61 Polyclonal Antibody

Catalog No.	Quantity
PIPA578022	100 μL

Catalog No. PIPA578022 Supplier Invitrogen™ Supplier No. PA578022

Description

Rabbit Polyclonal Antibody

Positive Control: HeLa (1X Brefeldin A for 24hr) Predicted Reactivity: Chicken (81%), Chimpanzee (99%), Bovine (92%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.

Specifications

• Antigen: CYR61
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1.34 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene: CCN1
• Gene Accession No.: O00622, P18406, Q9ES72
• Gene Alias: 3CH61; AI325051; CCN family member 1; CCN1; cellular communication network factor 1; Cyr61; cysteine rich angiogenic inducer 61; cysteine rich protein 61; cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; GIG1; IBP-10; IGF-binding protein 10; IGFBP10; IGFBP-10; insulin-like growth factor binding protein 10; insulin-like growth factor-binding protein 10; intermediate early; protein CYR61; Protein GIG1
• Gene Symbols: CCN1
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human CYR61. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 16007, 3491, 83476
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG