Cytarabine, 98%

Description

Cytarabine, CAS # 147-94-4, is an inhibitor of DNA synthesis that is used as an anticancer and antiviral agent. | CAS: 147-94-4 | C₉H₁₃N₃O₅ | 243.22 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Cytarabine is a nucleoside analog that acts as an antileukemic agent
• Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha
• Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells

Applications

• Has been used to study chemotherapeutic regimens in laboratory studies of leukemia
• Useful for laboratory studies of cytarabine resistance mechanisms
• At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members
• It can induce neuronal cell death via inducing γ-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks

Specifications

Chemical Identifiers

• CAS: 147-94-4
• Molecular Formula: C₉H₁₃N₃O₅
• Molecular Weight (g/mol): 243.22
• InChI Key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
• Synonym: cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine
• PubChem CID: 6253
• ChEBI: CHEBI:28680
• IUPAC Name: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O

• Melting Point: 220.0°C
• Assay Percent Range: 97.5% min. (HPLC)
• Packaging: Glass bottle
• Quantity: 100 mg
• Merck Index: 152781
• Solubility Information: Solubility in water: soluble. Other solubilities: soluble in dmso, ethanol
• Formula Weight: 243.22
• Percent Purity: 98%
• Chemical Name or Material: Cytarabine

Safety and Handling

Hazard Category	Serious eye damage/eye irritation (category 2), Germ cell mutagenicity (category 2), Reproductive toxicity (category 2), Skin sensitisation (category 1)
Hazard Statement	Causes serious eye irritation, Suspected of causing genetic defects, Suspected of damaging fertility or the unborn child, May cause an allergic skin reaction
EINECSNumber	205-705-9

SDS

RUO – Research Use Only