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Invitrogen™ Cytohesin 2 Monoclonal Antibody (10A12)
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Catalog No. MA1061
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100 μg
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MA1061 100 μg
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Catalog No. MA1061 Supplier Invitrogen™ Supplier No. MA1061
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Mouse Monoclonal Antibody

MA1-061 detects recombinant human and mouse cytohesin-2 (ARNO). MA1-061 has been successfully used in IHC (P), immunoprecipitation and IF procedures. By immunoprecipitation this antibody efficiently precipitates GFP-labeled ARNO. MA1-061 does not work in Western blot procedures. The MA1-061 immunogen is purified, His-tagged cytohesin-2.

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cytohesin 2
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry
Classification Monoclonal
Clone 10A12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene CYTH2
Gene Accession No. P63034, Q99418
Gene Alias ARF exchange factor; ARF nucleotide binding site opener; ARF nucleotide-binding site opener; ARNO; CLM2; CTC-273B12.8; CTS18; CTS18.1; Cyth2; cytohesin 2; cytohesin-2; mSec7-2; PH, SEC7 and coiled-coil domain-containing protein 2; pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2); pleckstrin homology, Sec7 and coiled-coil domains 2; pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2); Protein ARNO; PSCD2; PSCD2L; Sec7; SEC7 homolog B; Sec7b; SEC7L; Sec7p-L; Sec7p-like
Gene Symbols CYTH2
Host Species Mouse
Immunogen Purified, His-tagged cytohesin-2.
Purification Method PEG precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19158, 9266
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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