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Invitrogen™ Cytokeratin 4 Monoclonal Antibody (6B10)
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Catalog No. 01671396
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Catalog No. Quantity
01-671-396 1 mL
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Catalog No. 01-671-396 Supplier Invitrogen™ Supplier No. MA135558
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Description

Mouse Monoclonal Antibody

The antibody stains non-cornifying squamous epithelium and transitional epithelium of the bladder, cells in certain ciliated pseudo-stratified epithelia and ductal epithelia of various exocrine glands. In immunoblotting experiments the antibody was shown to recognize only cytokeratin no.4 (59 kDa).

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between approximately40 kDa and approximately68 kDa and isoelectric pH between 4. 9-7. 8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cytokeratin 4
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 6B10
Concentration 15 μg/mL
Conjugate Unconjugated
Formulation Tissue culture supernatant with 10mM sodium azide
Gene KRT4
Gene Accession No. P19013
Gene Alias 57kd keratin; 57kDa keratin; AW108092; cb59; CK4; CK-4; CYK4; cytokeratin; cytokeratin 4; cytokeratin-4; Cytoskeletal 57 kDa keratin; etID20321.6; intermediate filament protein; K4; Kb4; keratin 4; keratin 4, type II; keratin 8; keratin complex 2, basic, gene 4; keratin, type II cytoskeletal 4; Keratin-4; Krt-2.4; Krt2-4; Krt4; krt4 {ECO:0000250; krt4 protein; krt8; type II basic cytokeratin; type II keratin Kb4; type-II keratin Kb4; UniProtKB:P19013}; WSN1; wu:fa91a11; wu:fd19e09; wu:fl23c09; zf-K8
Gene Symbols KRT4
Host Species Mouse
Immunogen Cytokeratin purified from human esophagus.
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3851
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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