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Cytokeratin, pan Antibody (AE-1/AE-3), Alexa Fluor™ 647, R&D Systems™
SDP

Catalog No. NBP233200Y
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NBP233200Y 0.1 mL
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Catalog No. NBP233200Y Supplier R&D Systems Supplier No. NBP233200AF647

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Description

A Novus product, part of R&D Systems. Mouse Monoclonal Antibody has been used in 2 publications

pan Cytokeratin Monoclonal specifically detects pan Cytokeratin in Bovine, Canine, Chicken, Human, Monkey, Mouse, Rabbit, Rat, Reptile, Zebrafish samples. It is validated for CyTOF, Dual RNAScope ISH-IHC, Flow Cytometry, Flow Cytometry (Intracellular Staining), Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Single Cell Western, Western Blot.

Specifications

Antigen pan Cytokeratin
Applications CyTOF, Dual RNAScope ISH-IHC, Flow Cytometry, Flow Cytometry (Intracellular Staining), Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Single Cell Western, Western Blot
Classification Monoclonal
Clone AE-1/AE-3
Conjugate Alexa Fluor 647
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular)
Gene Symbols KRT1
Host Species Mouse
Immunogen This Cytokeratin, pan Antibody (AE-1/AE-3) was developed against total keratin isolated from human epidermal callus was used as immunogen to generate the pan cytokeratin antibodies AE1 + AE3 (Woodcock-Mitchell, 1982).
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Apoptosis, Cancer, Cell Biology, Cellular Markers, Signal Transduction
Primary or Secondary Primary
Gene ID (Entrez) 3848
Test Specificity Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
Target Species Bovine, Canine, Chicken, Human, Monkey, Mouse, Rabbit, Rat, Reptile, Zebrafish
Content And Storage Store at 4C in the dark.
Product Type Antibody
Form Purified
Isotype IgG1 κ
Product Line Novus
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