Thermo Scientific Chemicals D-Mannosamine hydrochloride, 98%

Description

CAS: 5505-63-5 | C6H14ClNO5 | 215.63 g/mol

D-Mannosamine hydrochloride is used in the synthesis of non-natural Mannac analogs for the expression of thiols on cell-surface sialic acids. It is also used to investigate and screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. It acts as a precursor of N-propanoyl mannosamine and other N-acyl precursors of sialic acid (N-acyl neuraminic acids). It is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery through M cells of Peyer's patches.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
D-Mannosamine hydrochloride is used in the synthesis of non-natural Mannac analogs for the expression of thiols on cell-surface sialic acids. It is also used to investigate and screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. It acts as a precursor of N-propanoyl mannosamine and other N-acyl precursors of sialic acid (N-acyl neuraminic acids). It is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery through M cells of Peyer′s patches.

Solubility
Soluble in water and methanol.

Notes
Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 5505-63-5
• Molecular Formula: C6H14ClNO5
• Molecular Weight (g/mol): 215.63
• MDL Number: MFCD00064557
• InChI Key: CBOJBBMQJBVCMW-DEZHIRTDSA-N
• Synonym: 2-amino-2-deoxy-d-mannosehydrochloride
• PubChem CID: 133109008
• IUPAC Name: (2R,3S,4R,5S)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride
• SMILES: C(C(C(C(C(C=O)N)O)O)O)O.Cl

• Melting Point: 168°C (decomposition)
• Color: White
• Quantity: 500 mg
• Sensitivity: Hygroscopic
• Solubility Information: Soluble in water and methanol.
• Optical Rotation: −4° (c=2 in Water)
• Formula Weight: 215.63
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: D-Mannosamine hydrochloride

Safety and Handling

Hazard Category	H302-H315-H317-H319-H335
Precautionary Statement	P261-P264b-P270-P271-P272-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P310-P330-P333+P313-P362-P501c
EINECSNumber	226-847-8
TSCA	Yes
Recommended Storage	Keep cold; Store under Argon

SDS

RUO – Research Use Only