Invitrogen™ DACH1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552968

Catalog No. PIPA552968

Description

Immunogen sequence: PKRTQSVTSP ENSHIMPHSV PGLMSPGIIP PTGLTAAAAA AAAATNAAIA EAMKVKKIKL EAMSNYHASN NQHGADSENG DMNSSVGSSD GSWDKETLPS SPSQGPQASI THPRMPGARS LPLSHPLNHL QQSHLLPNGL ELP Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 88%.

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.

Specifications

• Antigen: DACH1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dach1
• Gene Alias: Dac; dac homolog; DACH; Dach1; dachshund 1; dachshund 1 (Drosophila); dachshund family transcription factor 1; dachshund homolog 1; FLJ10138; OTTHUMP00000040839; RP11-512J14.1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1602
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UI36
• Gene Symbols: Dach1
• Immunogen: Recombinant protein corresponding to Human DACH1. Recombinant protein control fragment (Product #RP-89667).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG