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Invitrogen™ DACH1 Polyclonal Antibody
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Catalog No. PIPA552968
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PIPA552968 100 μL
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Catalog No. PIPA552968 Supplier Invitrogen™ Supplier No. PA552968
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PKRTQSVTSP ENSHIMPHSV PGLMSPGIIP PTGLTAAAAA AAAATNAAIA EAMKVKKIKL EAMSNYHASN NQHGADSENG DMNSSVGSSD GSWDKETLPS SPSQGPQASI THPRMPGARS LPLSHPLNHL QQSHLLPNGL ELP Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 88%.

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DACH1
Applications ChIP Assay, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Dach1
Gene Accession No. Q9UI36
Gene Alias Dac; dac homolog; DACH; Dach1; dachshund 1; dachshund 1 (Drosophila); dachshund family transcription factor 1; dachshund homolog 1; FLJ10138; OTTHUMP00000040839; RP11-512J14.1
Gene Symbols Dach1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DACH1. Recombinant protein control fragment (Product #RP-89667).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1602
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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