Invitrogen™ DACH1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106272

Catalog No. PIPA5106272

Description

Antibody detects endogenous levels of total DACH1.

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.

Specifications

• Antigen: DACH1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dach1
• Gene Alias: Dac; dac homolog; DACH; Dach1; dachshund 1; dachshund 1 (Drosophila); dachshund family transcription factor 1; dachshund homolog 1; FLJ10138; OTTHUMP00000040839; RP11-512J14.1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13134, 1602, 306096
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9QYB2, Q9UI36
• Gene Symbols: Dach1
• Immunogen: A synthesized peptide derived from human DACH1(Accession Q9UI36), corresponding to amino acid residues S160-L210.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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