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Invitrogen™ DACH1 Polyclonal Antibody
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Catalog No. PIPA5106272
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PIPA5106272 100 μL
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Catalog No. PIPA5106272 Supplier Invitrogen™ Supplier No. PA5106272
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DACH1.

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DACH1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Dach1
Gene Accession No. Q9QYB2, Q9UI36
Gene Alias Dac; dac homolog; DACH; Dach1; dachshund 1; dachshund 1 (Drosophila); dachshund family transcription factor 1; dachshund homolog 1; FLJ10138; OTTHUMP00000040839; RP11-512J14.1
Gene Symbols Dach1
Host Species Rabbit
Immunogen A synthesized peptide derived from human DACH1(Accession Q9UI36), corresponding to amino acid residues S160-L210.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13134, 1602, 306096
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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