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Invitrogen™ DACT1 Polyclonal Antibody
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Catalog No. PIPA523216
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100 μg
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PIPA523216 100 μg
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Catalog No. PIPA523216 Supplier Invitrogen™ Supplier No. PA523216
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Description

Rabbit Polyclonal Antibody

DACT1 Polyclonal Antibody for Western Blot, IHC (P)

Dapper homolog 1, an ortholog of Xenopus Dpr, antagonizes Wnt signaling by promoting Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism. Dapper homolog 1 acts as an interacting protein for Dvl, and the interaction is formed between the DEP (Dishevelled, Egl-10, and pleckstrin) domain of Dvl and the central and C-terminal regions of Dapper homolog 1. The gene for human Dapper homolog 1 is localized on chromosomal region 14q23.1. The protein impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. The protein is also required for normal notochord formation and is downregulated in hepatocellular carcinomas (HCC). It is expressed in human liver and various other tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DACT1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene DACT1
Gene Accession No. Q6QZN6, Q8R4A3, Q9NYF0
Gene Alias 4921528D17Rik; AI115603; dact1; dact1.S; dact1-a; dact1-b; DAPPER; dapper 1; dapper 1-A; dapper antagonist of catenin 1; Dapper homolog 1; dapper homolog 1, antagonist of beta-catenin; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 1; dapper1; dapper1b; dishevelled binding antagonist of beta catenin 1; dishevelled-binding antagonist of beta-catenin 1; dishevelled-binding antagonist of beta-catenin 1 S homeolog; dishevelled-interacting protein; dpr; dpr1; frd1; FRODO; frodo 1; frodo homolog; Frodo1; functional regulator of dsh in ontogenesis; HDPR1; Hepatocellular carcinoma novel gene 3 protein; heptacellular carcinoma novel gene 3; HNG3; MDpr1; MTNG3; RGD1564008; signaling protein; thyex3; thymus expressed gene 3; thymus-expressed novel gene 3 protein; XDpr; XDpr1b; XELAEV_18041122mg
Gene Symbols DACT1, dact1.S
Host Species Rabbit
Immunogen A portion of amino acids 725-775 of human Dapper homolog 1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 398315, 405799, 500666, 51339, 59036, 723789
Target Species Human, Mouse, Rat, Monkey, Chicken, Frog, Zebrafish
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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