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Invitrogen™ DAD1 Polyclonal Antibody
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Catalog No. PIPA520062
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100 μg
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Catalog No. Quantity
PIPA520062 100 μg
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Catalog No. PIPA520062 Supplier Invitrogen™ Supplier No. PA520062
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Description

Rabbit Polyclonal Antibody

Despite its predicted molecular weight, DAD1 often migrates at ~22kDa in SDS-PAGE. A suggested positive control is HepG2 cell lysate. PA5-20062 can be used with blocking peptide PEP-0181.

Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death, a process important for normal organism development and tissue homeostasis. DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity. Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death. Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DAD1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene DAD1
Gene Accession No. P61803, P61804
Gene Alias AI323713; Dad1; DAD-1; Defender against cell death 1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Oligosaccharyl transferase subunit DAD1; oligosaccharyltransferase 2 homolog; oligosaccharyltransferase subunit 2 (non-catalytic); OST2
Gene Symbols DAD1
Host Species Rabbit
Immunogen A peptide corresponding to 14 amino acids near the C-terminus of human DAD1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13135, 1603
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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