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Cayman Chemical DAF-2 diacetate, 205391-02-2, 250ug
SDP

Supplier:  Cayman Chemical 85165250

Encompass_Preferred

Molecular Formula C24H18N2O7, Purity ≥95%, Formula Weight 446.4, Synonyms: 2-(3,6-diacetyloxy-4,5-diamino-9H-xanthen-9-yl)-benzoic acid, 4,5-Diaminofluorescein diacetate; DAF-2 diacetate is a sensitive fluorescent indicator for the detection and bioimaging of NO.{6360,6632} It is a cell-permeable derivative of DAF-2. Upon entry into the cell, DAF-2 diacetate is transformed into the less cell-permeable DAF-2 by cellular esterases thus preventing loss of signal due to diffusion of the molecule from the cell. In the presence of oxygen, DAF-2 reacts with NO to yield the highly fluorescent triazolofluorescein (DAF-2T). Fluorescence is monitored using excitation and emission wavelengths of 485 and 538 nm, respectively.{6632} At neutral pH the detection limit for NO is 2-5 nM. DAF-2 diacetate can be utilized in cells which produce small amounts of NO, such as endothelial cells, as well as in cells which generate large amount of NO, such as macrophages.{6360,6632}.

Catalog No. NC0190930


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