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Tocris Bioscience™ dBET1

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Quantity:
5 mg
Description
Degrader (PROTAC®) comprising BET bromodomain antagonist (+)-JQ1 (Cat.No. 4499) conjugated to a cereblon E3 ubiquitin ligase ligand. Depletes BET bromodomains in cancer cell lines in vitro (EC50 = 430 nM in breast cancer cells) and induces apoptosis. Delays tumor growth and downregulates MYC in mice bearing human AML xenografts.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Specifications
Specifications
Chemical Name or Material | (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
CAS | 1799711-21-9 |
Assay Percent Range | >98% |
Quantity | 5 mg |
Molecular Formula | C38H37ClN8O7S |
Formula Weight | Observed MW: 785.27 |
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