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Tocris Bioscience™ dBET1
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Catalog No. 63275
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63-275 5 mg
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Catalog No. 63-275 Supplier Tocris Bioscience™ Supplier No. 6327/5
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Description

(+)-JQ1 based Degrader (PROTAC™) targeting BET bromodomains, active in vivo

Degrader (PROTAC®) comprising BET bromodomain antagonist (+)-JQ1 (Cat.No. 4499) conjugated to a cereblon E3 ubiquitin ligase ligand. Depletes BET bromodomains in cancer cell lines in vitro (EC50 = 430 nM in breast cancer cells) and induces apoptosis. Delays tumor growth and downregulates MYC in mice bearing human AML xenografts.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
CAS 1799711-21-9
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C38H37ClN8O7S
Formula Weight Observed MW: 785.27
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