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DBZ

γ-secretase inhibitor; inhibits Notch pathway

Supplier:  R&D Systems 4489/50

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Catalog No. 44-895-0


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Description

Description

DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the cleavage of amyloid precursor protein into Aβ40. DBZ promotes cochlear supporting cell proliferation and hair cell mitotic regeneration in neonatal mice. DBZ in combination with iDOT1L enables maintenance of human na?ve-state pluripotency in non-hypoxic conditions.

DBZ synthesized to Ancillary Material Grade also available.

Specifications

Specifications

DBZ
>98%
C26H23F2N3O3
209984-56-5
50 mg
463.48
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Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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