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Tocris Bioscience™ DBZ
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Catalog No. 448950
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Catalog No. Quantity
44-895-0 50 mg
44-891-0 10 mg
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Catalog No. 44-895-0 Supplier Tocris Bioscience™ Supplier No. 4489/50
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Description

γ-secretase inhibitor; inhibits Notch pathway

DBZ is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and 1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the cleavage of amyloid precursor protein into Aβ40. DBZ promotes cochlear supporting cell proliferation and hair cell mitotic regeneration in neonatal mice. DBZ in combination with iDOT1L enables maintenance of human na?ve-state pluripotency in non-hypoxic conditions.

DBZ synthesized to Ancillary Material Grade also available.

Specifications

Chemical Name or Material DBZ
CAS 209984-56-5
Assay Percent Range >98%
Quantity 50 mg
Molecular Formula C26H23F2N3O3
Formula Weight 463.48
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