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Apexbio Technology LLC DC260126 346692-04-4 10mg
SDP

Supplier:  Apexbio Technology LLC C549510

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DC260126 (CAS 346692-04-4) is a small-molecule antagonist of G protein-coupled receptor 40 (GPR40/FFAR1) a receptor activated by medium- and long-chain free fatty acids primarily in pancreatic -cells DC260126 inhibits GPR40-mediated intracellular calcium increases induced by fatty acids such as linoleic oleic palmitoleic and lauric acids with reported IC50 values in the low micromolar range In cellular assays it attenuates GTP-loading and ERK1/2 phosphorylation as well as glucose-stimulated insulin secretion potentiated by palmitic acid In db/db mice DC260126 reduces blood insulin levels improves insulin sensitivity and decreases -cell apoptosis This compound is valuable for probing GPR40-mediated pathways and -cell function in metabolic disease research

Catalog No. 50-000-88299


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