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Invitrogen™ DCC Polyclonal Antibody
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Catalog No. PIPA564420
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100 μL
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PIPA564420 100 μL
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Catalog No. PIPA564420 Supplier Invitrogen™ Supplier No. PA564420
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ACVRPTHPLR SFANPLLPPP MSAIEPKVPY TPLLSQPGPT LPKTHVKTAS LGLAGKARSP LLPVSVPTAP EVSEESHKPT EDSANVYEQD DLSEQMAS Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DCC
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DCC
Gene Accession No. P43146
Gene Alias C030036D22Rik; Colorectal cancer suppressor; colorectal tumor suppressor; CRC18; CRCR1; Dcc; DCC netrin 1 receptor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; IGDCC1; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; MRMV1; Netrin receptor DCC; NTN1R1; putative colorectal tumor suppressor; tumor suppressor protein DCC
Gene Symbols DCC
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DCC. Recombinant protein control fragment (Product #RP-103895).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1630
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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