Invitrogen™ DCC Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564420

Catalog No. PIPA564420

Description

Immunogen sequence: ACVRPTHPLR SFANPLLPPP MSAIEPKVPY TPLLSQPGPT LPKTHVKTAS LGLAGKARSP LLPVSVPTAP EVSEESHKPT EDSANVYEQD DLSEQMAS Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Specifications

• Antigen: DCC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCC
• Gene Alias: C030036D22Rik; Colorectal cancer suppressor; colorectal tumor suppressor; CRC18; CRCR1; Dcc; DCC netrin 1 receptor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; IGDCC1; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; MRMV1; Netrin receptor DCC; NTN1R1; putative colorectal tumor suppressor; tumor suppressor protein DCC
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1630
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P43146
• Gene Symbols: DCC
• Immunogen: Recombinant protein corresponding to Human DCC. Recombinant protein control fragment (Product #RP-103895).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG