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Invitrogen™ DDB2 Recombinant Rabbit Monoclonal Antibody (JE16-41)
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Catalog No. PIMA534832
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Quantity:
100 μL
Catalog No. Quantity
PIMA534832 100 μL
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Catalog No. PIMA534832

Supplier: Invitrogen™ MA534832

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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Daudi, human tonsil tissue, human liver cancer tissue, human skin tissue, A549.

Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DDB2
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone JE16-41
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene DDB2
Gene Accession No. Q92466
Gene Alias 2610043A19Rik; damage specific DNA binding protein 2; damage-specific DNA binding protein 2, 48kDa; damage-specific DNA-binding protein 2; DDB p48 subunit; DDB2; DDBb; DNA damage-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2; UV-DDB2; xeroderma pigmentosum group E protein; XPE
Gene Symbols DDB2
Host Species Rabbit
Immunogen Recombinant protein within Human DDB2 aa 180-427.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1643
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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