Invitrogen™ DDX60 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA561380

Catalog No. PIPA561380

Description

Immunogen sequence: PKADKEAHVM ANKLRKVKKS IEKQKIIDEK SQKKTRNVDQ SLIHEAEHDN LVKCLEKNLE IPQDCTYADQ KAVDTETLQK VFGRV Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 73%.

DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.

Specifications

• Antigen: DDX60
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DDX60
• Gene Alias: 9830118M07; DDX60; DEAD (Asp-Glu-Ala-Asp) box polypeptide 60; DEAD box protein 60; DEAD-box helicase 60; DEXD/H-box helicase 60; mCG11385-like; probable ATP-dependent RNA helicase DDX60; RGD1560014
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55601
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IY21
• Gene Symbols: DDX60
• Immunogen: Recombinant protein corresponding to Human DDX60. Recombinant protein control fragment (Product #RP-96654).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG