(+)-Dehydroisoandrosterone, 99%, Thermo Scientific Chemicals

Description

(+)-Dehydroisoandrosterone, CAS # 53-43-0, also known as androstenolone, is an endogenous steroid hormone precursor. It is an intermediate in the conversion of cholesterol to androgens and estrogens.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• (+)-Dehydroisoandrosterone is an endogenous steroid hormone precursor that acts as an intermediate in the conversion of cholesterol to androgens and estrogens

Applications

• It is an endogenous and naturally occurring steroid hormone produced largely by the adrenal glands, but also by the testes and ovaries
• It has been described that (+)-Dehydroisoandrosterone could have a role in the immune and stress response
• (+)-Dehydroisoandrosterone can be converted to testosterone, androstenedione, estradiol, and estrone
• (+)-Dehydroisoandrosterone is derived from cholesterol through the action of two cytochrome P450 enzymes
• It can induce both direct and indirect in vivo biological effects, by modulating GABA- α receptor and N-Methyl-D-aspartic acid (NMDA) receptor complexes.
• It can also increase pancreatic β cell insulin secretion and anti-glucocorticoid activity
• It is useful to detect excess adrenal activity since it is produced nearly exclusively by the adrenal glands

Specifications

Chemical Identifiers

• CAS: 53-43-0
• Molecular Formula: C₁₉H₂₈O₂
• Molecular Weight (g/mol): 288.42
• MDL Number: MFCD00003613
• InChI Key: FMGSKLZLMKYGDP-USOAJAOKSA-N
• Synonym: dehydroepiandrosterone, dhea, prasterone, dehydroisoandrosterone, androstenolone, trans-dehydroandrosterone, 3beta-hydroxyandrost-5-en-17-one, diandron, diandrone, psicosterone
• PubChem CID: 5881
• ChEBI: CHEBI:28689
• IUPAC Name: (3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
• SMILES: CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)O)C

• CAS Min %: 98.5
• CAS Max %: 100.0
• Melting Point: 146.0°C to 151.0°C
• Color: White
• Loss on Drying: 0.5% max. (105°C, 3 hrs)
• Infrared Spectrum: Authentic
• Assay Percent Range: 98.5% min. (HPLC)
• Packaging: Glass bottle
• Quantity: 50 g
• Beilstein: 08, IV, 994
• Merck Index: 15, 2875
• Specific Rotation Condition: +12° (25°C c=2,ethanol 96%)
• Specific Rotation: + 12.00
• Solubility Information: Solubility in water: practically insoluble. Other solubilities: soluble in benzene,alcohol and diethyl ether,sparingly soluble in chloroform and petrol. ether
• Formula Weight: 288.42
• Percent Purity: 99%
• Physical Form: Fine Crystalline Powder
• Chemical Name or Material: (+)-Dehydroisoandrosterone

Safety and Handling

EINECSNumber

200-175-5

SDS

RUO – Research Use Only