DES Mouse anti-Human, Clone: UMAB166, lyophilized, UltraMAB™

Catalog No.	Quantity
50-168-5036	100 μg

Catalog No. 50-168-5036 Supplier OriGene Supplier No. UM500107CF

Description

Mouse Monoclonal Antibody

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predomitly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

Specifications

• Antigen: DES
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: UMAB166
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative
• Gene: DES
• Gene Accession No.: P17661
• Gene Alias: CDCD3, CMD1F, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R
• Gene Symbols: DES
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human DES produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1674
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1