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Invitrogen™ Desmin Polyclonal Antibody
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Catalog No. PIPA595189
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100 μg
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PIPA595189 100 μg
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Catalog No. PIPA595189 Supplier Invitrogen™ Supplier No. PA595189
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Description

Rabbit Polyclonal Antibody

Human Desmin shares 97% amino acid (aa) sequences identity with both mouse and rat Desmin. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: rat heart tissue, rat skeletal muscle tissue, mouse C2C12 whole cell, mouse heart tissue, mouse skeletal muscle tissue. IHC: human lung cancer tissue, rat skeletal muscle tissue IHC-F: rat cardiac muscle tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Desmin
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.01mg sodium azide
Gene DES
Gene Accession No. P17661, P31001, P48675
Gene Alias CMD1I; CSM1; CSM2; DES; Desmin; desmin-like protein; FLJ12025; FLJ39719; FLJ41013; FLJ41793; I79_018932; intermediate filament protein; LGMD2R; MFM1; muscle-specific intermediate filament desmin; muscle-specific intermediate filament protein; mutant desmin p.K241E; SCPNK; similar to desmin
Gene Symbols DES
Host Species Rabbit
Immunogen E.coli-derived human Desmin recombinant protein (Position: M1-T304).
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13346, 1674, 64362
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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