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  6. Invitrogen™ Desmoglein 2 Monoclonal Antibody (CSTEM28), eBioscience™, Invitrogen™ 

Invitrogen™ Desmoglein 2 Monoclonal Antibody (CSTEM28), eBioscience™, Invitrogen™

Catalog No. 14915982
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14-915-982 100 μg
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Catalog No. 14-915-982 Supplier Invitrogen™ Supplier No. 14915982
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Description

Mouse Monoclonal Antibody

This monoclonal antibody CSTEM28 reacts with human desmoglein 2 (DSG2), a type 1 transmembrane protein belonging to the cadherin family. DSG2 is expressed by epithelial cells, cardiomyocytes, endothelial progenitors, and CD34+CD45dim hematopoietic stem and progenitor cells. This adhesion molecule forms cell-cell adhesion complexes called desmosomes that provide tensile strength to tissues that experience mechanical stress. Other than its role in desmosome formation, DSG2 plays a role in barrier integrity, adhesion, migration, cell apoptosis, proliferation, vasculogenic mimicry, and intracellular signaling. DSG2-expressing endothelial progenitor cells are pro-angiogenic, suggesting a role in vasculature formation. On hematopoietic stem and progenitor cells, DSG2 expression is highest on CD38-CD90+ multi-potent cells. DSG2 expression is progressively decreased as a function of differentiation, with DSG2 expression absent on mature lymphocytes. DSG2 also serves as a receptor for adenoviruses and can be shed by mucosal barriers in the intestine. This CSTEM28 antibody has been tested by flow cytometric analysis of the 2102ep cell line. This has also been tested by immunocytochemistry of fixed and permeabilized cells and can be used at less than or equal to 10 μg/mL. It is recommended the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE.

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Desmoglein 2
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone CSTEM28
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene DSG2
Gene Accession No. Q14126
Gene Alias AA408168; ARVC10; ARVD10; Cadherin family member 5; CDHF5; CMD1BB; D18Ertd293e; desmoglein 2; desmoglein-2; DSG2; DSG-2; HDGC; MGC117034; MGC117036; MGC117037
Gene Symbols DSG2
Host Species Mouse
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1829
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only.

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